Synthesis of aromatic α-amino acids via Meerwein arylation
نویسندگان
چکیده
منابع مشابه
Enantioselective Decarboxylative Arylation of α-Amino Acids via the Merger of Photoredox and Nickel Catalysis.
An asymmetric decarboxylative Csp(3)-Csp(2) cross-coupling has been achieved via the synergistic merger of photoredox and nickel catalysis. This mild, operationally simple protocol transforms a wide variety of naturally abundant α-amino acids and readily available aryl halides into valuable chiral benzylic amines in high enantiomeric excess, thereby producing motifs found in pharmacologically a...
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The direct decarboxylative arylation of α-amino acids has been achieved via visible light-mediated photoredox catalysis. This method offers rapid entry to prevalent benzylic amine architectures from an abundant biomass, specifically α-amino acid precursors. Significant substrate scope is observed with respect to both the amino acid and arene components.
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A method for the synthesis of α-amino acids by direct reductive carboxylation of aromatic imines with CO2 is described. The protocol employs readily available commercial reagents and serves as a one-step alternative to the Strecker synthesis.
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This study describes the preparation and description of four new complexes: Bu2Sn(AA)Cl (AA = glycine, DL = valine and L = leucine) and Bu2SnPhen2 (Phen = DL-phenylalanine). They were characterized by elemental analyses for carbon, hydrogen, nitrogen, chlorine and tin by infrared, 119mSn-Mössbauer and 119mSnRMN spectroscopies and by the applications of TG and DSC techniques in a dynamic helium ...
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Unnatural chiral α-amino acids are widely used in fields of organic chemistry, biochemistry and medicinal chemistry, and their synthesis has attracted extensive attention. Although the asymmetric synthesis provides some efficient protocols, noble and elaborate catalysts, ligands and additives are usually required which leads to high cost. Distinctly, it is attractive to make unnatural chiral α-...
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ژورنال
عنوان ژورنال: Canadian Journal of Chemistry
سال: 1967
ISSN: 0008-4042,1480-3291
DOI: 10.1139/v67-059